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Background and aims: Endogenous opioids function as negative factors affecting the growth has been established. The most influential factor in the growth and differentiation of the proliferating cells is the opioid growth factor (OGF). Recently, some studies have been completed about the effects of opioid growth factor in the pathogenesis of diabetes and the beneficial effects of inhibition of this growth pathway have been demonstrated. The aim of this study was to investigate the effect of inhibition of opioids growth pathway, in proliferation and growth of testicular germ cells and spermatogenesis following experimental diabetes in adult mice

romanian journal of diabetes nutrition and metabolic diseases

Investigation of Opioid Growth Factor Pathway Inhibition on the Histologic Structure of Testicular Tissue and Microscopic Indices of Spermatogenesis in Adult Diabetic Mice