Open AccessA Case of Possible Hypersensitivity Reactions to Human Insulin
Author(s) -
Eduard Adamescu,
Adriana Mihaela Tudose,
Nicolae Viorel Dumitrescu,
Carmen Dobjanschi
Publication year - 2016
Publication title -
romanian journal of diabetes nutrition and metabolic diseases
Language(s) - English
Resource type - Journals
eISSN - 2284-6417
pISSN - 2068-8245
DOI - 10.1515/rjdnmd-2016-0002
Subject(s) - medicine , insulin , maculopapular rash , desensitization (medicine) , sensitization , diabetes mellitus , rash , degranulation , type 1 diabetes , insulitis , allergy , hypersensitivity reaction , urticaria pigmentosa , dermatology , immunoglobulin e , immunology , endocrinology , antibody , receptor
Background: Insulin therapy is commonly used in diabetic patients. It represents the only option for patients with type 1 diabetes mellitus and could be part of the treatment plan for the patient with type 2 diabetes mellitus. Clinical appearance of hypersensitivity reactions to insulin vary significantly, depending on the immune mechanism involved. Many skin prick tests could be interpreted as positive reactions (either by using inappropriate concentrations or due to other mast cell degranulation causes)