Open AccessChronic Active Epstein–Barr Virus Infection
Author(s) -
Jun Li,
Shihong Li,
Guiqiang Wang,
Hong Zhao
Publication year - 2012
Publication title -
infection international/infection international (electronic edition)
Language(s) - English
Resource type - Journals
eISSN - 2544-0349
pISSN - 2095-2244
DOI - 10.1515/ii-2017-0018
Subject(s) - virus , epstein–barr virus , rash , virology , immunology , erythema , medicine , gammaherpesvirinae , interferon , peripheral blood mononuclear cell , pathology , biology , herpesviridae , viral disease , dermatology , biochemistry , in vitro
Chronic active Epstein-Barr virus (CAEBV) infection is a systemic Epstein-Barr virus (EBV) positive lymphoprolifetative disease characterized by fever, lymphadenopathy, splenomegaly, unusual pattern of anti- EBV antibodies, and/or increased EBV genomes in affected tissues. Most cases are from Asia. So far, there is hardly any adult case reported from mainland of China. We herein presented a 33-year-old man with fever, facial erythema and rash, lymphadenopathy, lower limbs weakness, splenomegaly and liver lesion. EBV VCA, EA and EBNA were all positive. EBV DNA could be found in serum and PBMC. In situ hybridization of EBV encoded RNA in skin and liver biopsy was positive. Viral load in serum decreased under interferon alpha therapy. To our knowledge, it’s the first adult case reported from mainland of China.