Open AccessGenetically Determined TNF-α Secretion Influences the Development of Dermatomyositis and Systemic Lupus Erythematosus
Author(s) -
Lyubomir Dourmishev,
Maria Hristova,
Zornitsa Kamenarska,
Alexey Savov,
Anton Vinkov,
Radka Kaneva,
Vanio Mitev
Publication year - 2018
Publication title -
folia medica/folia medica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 21
eISSN - 1314-2143
pISSN - 0204-8043
DOI - 10.1515/folmed-2017-0084
Subject(s) - dermatomyositis , medicine , pathogenesis , secretion , tumor necrosis factor alpha , immunology , linkage disequilibrium , allele , systemic disease , haplotype , immunopathology , gene , biology , genetics
Background: Abnormal secretion of TNF-α is known to play a role in the pathogenesis of dermatomyositis and systemic lupus erythematosus. Materials and methods: In the present study we have analyzed the concentrations of TNF-α in the sera of 30 patients with systemic lupus erythematosus (SLE), 28 with dermatomyositis (DM) and 30 healthy controls by standard ELISA tests. Results: We have found that -308A allele increases TNF-α secretion, while -1031C and -863A alleles decrease it. The -857C/T and 489G/A polymorphisms appeared in strong linkage disequilibrium (D’=0.93) but they did not seem to affect TNF-α secretion. Conclusion: TNF-α polymorphisms play a significant role in its secretion and influence the development of DM and SLE.