Open AccessLandolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells
Author(s) -
Oyinbo Charles Aidemise,
Patrick Sunday Igbigbi,
O. G. Avwioro
Publication year - 2016
Publication title -
folia medica/folia medica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 21
eISSN - 1314-2143
pISSN - 0204-8043
DOI - 10.1515/folmed-2016-0034
Subject(s) - neurodegeneration , cerebellum , oxidative stress , cerebellar cortex , purkinje cell , medicine , endocrinology , chemistry , neuroscience , pharmacology , biology , disease
Alcohol-induced cerebellar neurodegeneration is a neuroadaptation that is associated with chronic alcohol abuse. Conventional drugs have been largely unsatisfactory in preventing neurodegeneration. Yet, multimodal neuro-protective therapeutic agents have been hypothesised to have high therapeutic potential for the treatment of CNS conditions; there is yet a dilemma of how this would be achieved. Contrarily, medicinal botanicals are naturally multimodal in their mechanism of action.