Open AccessBone And Soft Tissue Changes In Patients With Spinal Cord Injury And Multiple Sclerosis
Author(s) -
Yannis Dionyssiotis,
Andreas F. Mavrogenis,
George Trovas,
G. Skarantavos,
Jannis Papathanasiou,
Panayiotis J. Papagelopoulos
Publication year - 2014
Publication title -
folia medica/folia medica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 21
eISSN - 1314-2143
pISSN - 0204-8043
DOI - 10.1515/folmed-2015-0002
Subject(s) - medicine , soft tissue , spinal cord injury , bone remodeling , multiple sclerosis , diabetes mellitus , spinal cord , coronary artery disease , bone tissue , adipose tissue , osteoporosis , bone mass , pathophysiology , muscle tissue , surgery , cardiology , pathology , endocrinology , psychiatry
In patients with spinal cord injury and multiple sclerosis, deterioration of body composition (changes in bone, fat and muscle mass) is associated with increased risk for diseases such as coronary artery heart disease, non-insulin dependent diabetes mellitus, lipid metabolism abnormalities, and osteoporotic fractures in these patients. Immobility leads to a changing pattern of loading in the paralyzed areas, and secondary alteration in structure. However, bone and soft tissue changes in these patients are usually neglected. The purpose of this article is to update on the pathophysiological mechanisms leading to bone and soft tissue changes, and to increase the awareness of the treating physicians with respect to bone, muscle and fat loss and their consequences aiming to obtain measures to prevent bone and soft tissue loss in these patients.