Open AccessCellular metabolism and lysosomal mTOR signaling
Author(s) -
Israel C. Nnah,
Khoosheh Khayati,
Radoslaw Dobrowolski
Publication year - 2015
Publication title -
cell death in therapy
Language(s) - English
Resource type - Journals
ISSN - 2353-7817
DOI - 10.1515/cdth-2015-0001
Subject(s) - mtorc1 , tfeb , anabolism , pi3k/akt/mtor pathway , lysosome , microbiology and biotechnology , mtorc2 , catabolism , function (biology) , biology , mechanistic target of rapamycin , metabolism , signal transduction , biochemistry , enzyme
Over the last few years extensive studies have linked the activity of mTORC1 to lysosomal function. These observations propose an intriguing integration of cellular catabolism, sustained by lysosomes, with anabolic processes, largely controlled by mTORC1. Interestingly, lysosomal function directly affects mTORC1 activity and is regulated by ZKSCAN3 and TFEB, two transcription factors and substrates of mTORC1. Thus, the lysosomal mTOR signaling complex represents a hub of cellular energy metabolism, and its dysregulation may lead to a number of human diseases. Here, we discuss the recent developments and highlight the open questions in this growing field.