Open AccessAdmittance‐based pressure–volume loops versus gold standard cardiac magnetic resonance imaging in a porcine model of myocardial infarction
Author(s) -
Hout Gerardus P. J.,
Jansen of Lorkeers Sanne J.,
Gho Johannes M. I. H.,
Doevendans Pieter A.,
Solinge Wouter W.,
Pasterkamp Gerard,
Chamuleau Steven A. J.,
Hoefer Imo E.
Publication year - 2014
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.287
Subject(s) - cardiology , ejection fraction , medicine , cardiac magnetic resonance imaging , myocardial infarction , magnetic resonance imaging , gold standard (test) , infarction , stroke volume , end diastolic volume , end systolic volume , nuclear medicine , radiology , heart failure
A novel admittance‐based pressure–volume system ( AS ) has recently been developed and introduced. Thus far, the new technique has been validated predominantly in small animals. In large animals it has only been compared to three‐dimensional echocardiography (3 DE ) where the AS showed to overestimate left ventricular ( LV ) volumes. To fully determine the accuracy of this device, we compared the AS with gold standard cardiac magnetic resonance imaging ( CMRI ) in a porcine model of chronic myocardial infarction ( MI ). Fourteen pigs were subjected to 90 min closed chest balloon occlusion of the left anterior descending artery. After 8 weeks of follow up, pigs were consecutively subjected to LV volume measurements by the AS , CMRI , and 3 DE under general anesthesia. The AS overestimated end diastolic volume ( EDV ; +20.9 ± 30.6 mL, P = 0.024) and end systolic volume ( ESV ; +17.7 ± 29.4 mL, P = 0.042) but not ejection fraction ( EF ; +2.46 ± 6.16%, P = NS ) compared to CMRI . Good correlations of EDV ( R = 0.626, P = 0.017) and EF ( R = 0.704, P = 0.005) between the AS and CMRI were observed. EF measured by the AS and 3 DE also correlated significantly ( R = 0.624, P = 0.030). After subjection of pigs to MI , the AS very moderately overestimates LV volumes and shows accurate measurements for EF compared to CMRI . This makes the AS a useful tool to determine cardiac function and dynamic changes in large animal models of cardiac disease.