Open AccessIn‐depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS‐CoV‐2 infection: A case series study
Author(s) -
Astley Camilla,
Badue Pereira Maria Fernanda,
Lima Marcos Santos,
Buchpiguel Carlos Alberto,
Carneiro Camila G.,
Sapienza Marcelo Tatit,
Leal Gabriela Nunes,
Prado Danilo Marcelo Leite,
Peçanha Tiago,
Sieczkowska Sofia Mendes,
Matsuo Olivia Mari,
Lindoso Livia,
Marques Heloisa Helena,
Silva Clovis Artur,
Gualano Bruno
Publication year - 2022
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.15201
Subject(s) - medicine , pericardial effusion , endothelial dysfunction , perfusion , cardiology
Abstract We assessed PET‐CT myocardial blood flow (MBF) using N‐13 ammonia, brachial flow‐mediated dilation, and cardiopulmonary exercise test in five post‐discarged MIS‐C survivors. None of the patients (median age: 9, range: 7‐18 years; 3 females; 2 males) had preexisting pediatric chronic conditions. At the follow‐up visit, two patients exhibited severe perfusion defect developed in the left ventricular cavity, suggesting extensive myocardial ischemia (MBF <2.0) and one patient showed persistent mild pericardial effusion. Others two patients demonstrated endothelial dysfunction. Nevertheless, all patients had lower predicted values in the V O 2peak , V O 2VAT , OUES, and O 2 Pulse (range: 35.2%–64.5%; 15.6%–38.2%; 1.0–1.3 L/min; 4–7 ml/beat), respectively. Our d suggested that previously health MIS‐C patients had impaired MBF, endothelial dysfunction and lower cardiopulmonary capacity at follow‐up analysis. Multidisciplinary further investigations should be conducted to reinforce these findings.