Open AccessNedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes
Author(s) -
Coyle Michael A.,
Goss Curtis S.,
Manz Wesley J.,
Greenshields Joel T.,
Chapman Robert F.,
Stager Joel M.
Publication year - 2022
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.15149
Subject(s) - medicine , nedocromil sodium , hypoxemia , exercise induced asthma , placebo , endurance training , diphenhydramine , anesthesia , histamine , heart rate , cardiology , physical therapy , asthma , blood pressure , alternative medicine , pathology
Exercise‐induced arterial hypoxemia (EIAH) has been observed in highly trained endurance athletes during near maximal exercise, which may be influenced by a histamine‐mediated inflammatory response at the pulmonary capillary‐alveolar membrane. In order to test this hypothesis, we examined whether the mast cell stabilizer nedocromil sodium (NS) and H 1 ‐receptor antagonist diphenhydramine HCL (DH) would ameliorate EIAH and mitigate the drop in arterial oxyhemoglobin saturation (S a O 2 ) during intensive exercise. Methods Seven highly trained male cross country runners (age, 21 ± 2 years; V̇O 2max , 74.7 ± 3.5 ml·kg −1 ·min −1 ) participated in the study. All subjects completed a maximal exercise treadmill test to exhaustion, followed by three 5‐min constant‐load exercise bouts at 70%, 80%, and 90% V̇O 2max . Prior to testing, subjects received either placebo (PL), NS, or DH. Results Compared to PL, there was a significant treatment effect on S a O 2 ( p < 0.001) for both NS and DH during both constant‐load exercise and at V̇O 2max . Post hoc tests revealed S a O 2 values, compared to PL, were significantly higher at V̇O 2max and during DH trials and higher with NS at constant‐load intensities except at 70% ( p = 0.13). Conclusion The findings provide further evidence that histamine contributes directly or indirectly to the development of EIAH during intense exercise in highly trained athletes.