Open AccessEffect of the order of concurrent training combined with resistance and high‐intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal muscle
Author(s) -
Shirai Takanaga,
Hanakita Hideto,
Uemichi Kazuki,
Takemasa Tohru
Publication year - 2021
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.14770
Subject(s) - glycolysis , glycogen , high intensity interval training , ribosomal protein s6 , endurance training , skeletal muscle , muscle hypertrophy , medicine , endocrinology , kinase , pi3k/akt/mtor pathway , interval training , phosphorylation , strength training , glycogen synthase , biology , metabolism , p70 s6 kinase 1 , biochemistry , signal transduction , physiology
Athletes train to improve strength and endurance to demonstrate maximum performance during competitions. Training methods vary but most focus on strength, endurance, or both. Concurrent training is a combination of two different modes of training. In this study, we combined resistance exercise (RE) and high‐intensity interval exercise (HIIE) to investigate the influence of the order of the concurrent training on signal molecules on hypertrophy and glycolysis in the skeletal muscle. The phosphorylation levels of mechanistic target of rapamycin (mTOR) signals, p70 S6 kinase (p70S6 K), ribosomal protein S6 (S6), and glycogen synthase kinase beta (GSK‐3β) were significantly increased in the HIIE first group compared with the control group. The combined training course did not affect the glycogen content and expression levels of proteins concerning glycolytic and metabolic capacity, suggesting that a combination of HIIE and RE on the same day, with HIIE prior to RE, improves hypertrophy response and glycolysis enhancement.