Open AccessThe role of Sfrp and DKK proteins in cardiomyocyte development
Author(s) -
Hsueh YingChang,
Hodgkinson Conrad P.,
Gomez Jose A.
Publication year - 2021
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.14678
Subject(s) - wnt signaling pathway , microbiology and biotechnology , lrp6 , signal transduction , biology , beta catenin , endogeny , chemistry , biochemistry
In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation.