Open AccessDoes depth of squat‐stand maneuver affect estimates of dynamic cerebral autoregulation?
Author(s) -
Batterham Angus P.,
Panerai Ronney B.,
Robinson Thompson G.,
Haunton Victoria J.
Publication year - 2020
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.14549
Subject(s) - transcranial doppler , medicine , autoregulation , cerebral autoregulation , hemodynamics , cardiology , middle cerebral artery , blood pressure , cerebral blood flow , squat , blood flow , anesthesia , physical medicine and rehabilitation , ischemia
Repeated squat‐stand maneuvers (SSM) are an effective way of measuring dynamic cerebral autoregulation (dCA), but the depth of SSM required to improve dCA estimations has never been studied. We compared beat‐to‐beat cerebral hemodynamic parameters between maximal depth SSM (SSM D ) and a shallower alternative (SSM S ) in two age groups (younger [20–34 years] vs. older [50–71 years]) at a frequency of 0.05 Hz. Cerebral blood flow velocity, continuous blood pressure (BP) and end‐tidal CO 2 (EtCO 2 ) were measured using transcranial Doppler ultrasound, the Finometer device, and capnography, respectively. Coherence (at 0.05 Hz) was significantly higher in both SSM recordings compared to spontaneous BP oscillations at baseline standing (B S ). Median (IQR) autoregulation index (ARI) was reduced during SSM D (4.46 [4.03–5.22], p < .01) compared to SSM S (5.96 [5.40–6.69]) and B S (6.03 [5.20–6.49], p < .01) with similar relative differences also observed for phase (at 0.05 Hz). End‐tidal CO 2 was increased in SSM D (38.3 ± 3.7 mmHg, p < .01) compared to both SSM S (36.6 ± 3.6 mmHg) and B S (35.5 ± 3.2 mmHg). The older group demonstrated significantly lower ARI and phase estimates during SSM and found SSM S more effortful than SSM D . In conclusion, both SSM D and SSM S are effective at estimating dCA, and dCA appears to be less efficient during maximal depth SSM compared to baseline rest or a shallower alternative.