Open AccessVitamin D is not required for adaptive immunity to listeria
Author(s) -
Baisa Gary A.,
Plum Lori,
Marling Steve,
Seeman Jeremy,
DeLuca Hector F.
Publication year - 2019
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.14209
Subject(s) - listeria , acquired immune system , immunity , listeria monocytogenes , immune system , vitamin d and neurology , vitamin , immunology , listeria infection , biology , innate immune system , ex vivo , in vivo , medicine , endocrinology , bacteria , microbiology and biotechnology , genetics
Although ex vivo research suggests that vitamin D may play a role in innate and adaptive immunity, clear in vivo evidence is lacking. We have tested whether severe vitamin D deficiency alters the ability of mice to resist infection by Listeria. Our results show that vitamin D deficiency does not affect the LD 50 of naïve mice in response to Listeria. To study the adaptive immune response, the LD 50 for Listeria‐immunized mice was determined for vitamin D‐deficient and vitamin D‐sufficient mice. Although the LD 50 clearly increased by immunization with inactivated Listeria, there was no effect of vitamin D deficiency on survival of mice infected with wild‐type Listeria. Thus, in this model of adaptive immunity, we could find no evidence of a role for vitamin D.