Open AccessExercise training suppresses scavenger receptor CD36 expression in kupffer cells of nonalcoholic steatohepatitis model mice
Author(s) -
Kawanishi Noriaki,
Mizokami Tsubasa,
Yada Koichi,
Suzuki Katsuhiko
Publication year - 2018
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13902
Subject(s) - cd36 , scavenger receptor , medicine , endocrinology , nonalcoholic steatohepatitis , steatosis , receptor , peroxisome proliferator activated receptor , steatohepatitis , nonalcoholic fatty liver disease , fatty liver , cholesterol , lipoprotein , disease
Although nonalcoholic steatohepatitis ( NASH ) is an important component of the metabolic syndrome, scavenger receptor CD 36 also modulates NASH development. This study aimed to clarify whether exercise training suppresses CD 36 expression in a mouse model of NASH . Male C57 BL /6 mice were divided into four groups: normal diet ( ND ) sedentary, ND exercise, high‐fat diet and high‐fructose water ( HFF ) sedentary, and HFF exercise groups. The exercise groups were trained on a motorized treadmill at running speeds of 15–20 m/min for 60 min/day, 5 times/week for 16 weeks. CD 36 cell surface expression of hepatic resident macrophages, peroxisome proliferator‐activated receptor ( PPAR )‐γ protein, and mRNA levels in the liver were increased in HFF sedentary mice but were attenuated in HFF exercise mice. Hepatic resident macrophages were significantly lower in HFF exercise mice than in HFF sedentary mice. Our findings indicated that exercise training reduced macrophage quantity in the liver, and downregulated CD 36 and PPAR ‐γ expression in liver and macrophages.