Open AccessCorrected whole blood biomarkers – the equation of Dill and Costill revisited
Author(s) -
Matomäki Pekka,
Kainulainen Heikki,
Kyröläinen Heikki
Publication year - 2018
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13749
Subject(s) - context (archaeology) , whole blood , biomarker , plasma volume , medicine , hemoglobin , blood volume , chemistry , biology , biochemistry , paleontology
An exercise bout or a dehydration often causes a reduction in plasma volume, which should be acknowledged when considering the change in biomarkers before and after the plasma changing event. The classic equation from Dill and Costill (1974, J. Appl. Physiol., 37, 247–248) for plasma volume shift is usually utilized in such a case. Although this works well with plasma and serum biomarkers, we argue in this note that this traditional approach gives misleading results in the context of whole blood biomarkers, such as lactate, white cells, and thrombocytes. In this study, we demonstrate that to calculate the change in the total amount of circulating whole blood biomarker, one should utilize a formulaBM post BM pre × H b preH b post− 1 .Here Hb and BM are, respectively, the concentrations for the hemoglobin and for the inspected whole blood biomarker before (pre) and after (post) the plasma changing incident.