Open AccessThe combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults
Author(s) -
Lithgow Hannah Margaret,
FloridaJames Geraint,
Leggate Melanie
Publication year - 2018
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13684
Subject(s) - medicine , endocrinology , glycemic , overweight , vitamin d and neurology , insulin , triglyceride , vitamin , obesity , placebo , type 2 diabetes , diabetes mellitus , cholesterol , alternative medicine , pathology
High‐intensity intermittent training ( HIIT ) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2 DM ). Independently, a low vitamin D status has also been linked to the prevalence of T2 DM . The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ± 9 year; BMI , 31.4 ± 2.8 kg·m −2 ) completed 6 weeks HIIT , and were randomized to ingest 100 μ g·day ‐1 of vitamin D 3 or placebo. Response to an oral glucose tolerance test ( OGTT ) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT , accompanied by a decrease in glucose (829 ± 110 to 786 ± 139 mmol·h −1 ·L −1 ; P = 0.043) and insulin (8101 ± 4755–7024 ± 4489 mU·h −1 ·L −1 ; P = 0.049) area under the curve ( AUC ). Supplementation increased 25‐hydroxyvitamin D 3 concentration by 120% to a sufficiency status ( P < 0.001). However, the consumption of vitamin D 3 seemed to attenuate the glucose response during an OGTT . Triglyceride content was lowered following the intervention ( P = 0.025). There was no effect of the intervention on insulin sensitivity ( IS ) indices: ISI M atsuda and HOMA ‐ IR . Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D 3 supplementation did not proffer any additional positive effects on the measured indices of metabolic health.