Open AccessA comparison of postoperative morphometric and hemodynamic changes between saphenous vein and left internal mammary artery grafts
Author(s) -
Fan Tingting,
Feng Yundi,
Feng Feng,
Yin Zhongjie,
Luo Dayou,
Lu Yuan,
Xu Yingjin,
Tan Wenchang,
Huo Yunlong
Publication year - 2017
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13487
Subject(s) - medicine , hemodynamics , anastomosis , cardiology , revascularization , vein , lumen (anatomy) , artery , mammary artery , surgery , myocardial infarction
There is higher long‐term failure of the saphenous vein graft ( SVG ) compared with the left internal mammary artery ( LIMA ) graft, which is affected by the hemodynamic environment. A comprehensive analysis of postoperative structure‐function changes is important to study the atherogenesis in the SVG . A comparison of morphometric and hemodynamic parameters was carried out between LIMA grafts and SVG s and between different time points postoperatively. Various parameters were obtained from the image reconstruction and flow simulation in patients, who underwent CT exams for ~1 year, 5 and 10 years after revascularization. Morphometric data showed a decrease in lumen size in the entire SVG and anastomosis of different patients in a sequence of ~1 year, 5 and 10 years postoperatively despite negligible changes of LIMA size. Computational results indicated the fourfold increased surface area ratio ( SAR ) of low time‐averaged wall shear stress ( TAWSS ) in the SVG and anastomosis at postoperative 10 years than that at postoperative ~1 year. The SAR of high TAWSS gradient ( TAWSSG ) at the distal anastomosis between SVG and coronary arteries was significantly higher (14 ± 9% vs. 6 ± 8%) than that in the LIMA group at postoperative ~1 year. There were strong correlations between morphometric and hemodynamic parameters in the SVG and distal anastomosis at various time points postoperatively, which showed deterioration relevant to persistent diffuse diseases at postoperative ~10 years.