Open AccessMuscle fiber capillarization as determining factor on indices of insulin sensitivity in humans
Author(s) -
Snijders Tim,
Nederveen Joshua P.,
Verdijk Lex B.,
Houben Alfons J. H. M.,
Goossens Gijs H.,
Parise Gianna,
Loon Luc J. C.
Publication year - 2017
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13278
Subject(s) - postprandial , medicine , skeletal muscle , endocrinology , insulin , muscle biopsy , insulin resistance , glucose tolerance test , insulin sensitivity , vastus lateralis muscle , sarcopenia , biopsy
To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the m . vastus lateralis of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test ( OGTT ). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low ( LOW ) or high ( HIGH ) muscle fiber capillarization (capillary‐to‐fiber perimeter exchange ( CFPE ) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results. Whereas no differences in blood glucose concentrations were observed between groups during the OGTT , the postprandial increase in plasma insulin concentrations was significantly greater in the LOW compared to the HIGH muscle fiber capillarization group ( P < 0.05). Skeletal muscle fiber capillarization may determine insulin sensitivity in humans.