Open AccessDecreased transcriptional corepressor p107 is associated with exercise‐induced mitochondrial biogenesis in human skeletal muscle
Author(s) -
Bhattacharya Debasmita,
Ydfors Mia,
Hughes Meghan C.,
Norrbom Jessica,
Perry Christopher G. R.,
Scimè Anthony
Publication year - 2017
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13155
Subject(s) - mitochondrial biogenesis , skeletal muscle , corepressor , endurance training , mitochondrion , nrf1 , biology , microbiology and biotechnology , transcriptional regulation , medicine , endocrinology , repressor , gene , gene expression , genetics
Increased mitochondrial content is a hallmark of exercise‐induced skeletal muscle remodeling. For this process, considerable evidence underscores the involvement of transcriptional coactivators in mediating mitochondrial biogenesis. However, our knowledge regarding the role of transcriptional corepressors is lacking. In this study, we assessed the association of the transcriptional corepressor Rb family proteins, Rb and p107, with endurance exercise‐induced mitochondrial adaptation in human skeletal muscle. We showed that p107, but not Rb, protein levels decrease by 3 weeks of high‐intensity interval training. This is associated with significant inverse association between p107 and exercise‐induced improved mitochondrial oxidative phosphorylation. Indeed, p107 showed significant reciprocal correlations with the protein contents of representative markers of mitochondrial electron transport chain complexes. These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise.