Open AccessLack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population
Author(s) -
Yvert Thomas,
MiyamotoMikami Eri,
Murakami Haruka,
Miyachi Motohiko,
Kawahara Takashi,
Fuku Noriyuki
Publication year - 2016
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.13003
Subject(s) - endurance training , athletes , bonferroni correction , population , medicine , genotype , physical therapy , genetics , biology , gene , statistics , mathematics , environmental health
Abstract The aim of this study was to examine a polygenic profile related to endurance performance, based on current knowledge, in the Japanese population. We analyzed 21 genetic polymorphisms that have been reported to be associated with endurance performance and its related phenotypes in 175 endurance runners (60 international‐, 94 national‐, and 21 regional‐level) and 649 controls in the Japanese population. Then, we calculated the total genotype score ( TGS ) (maximum value of 100 for the theoretically optimum polygenic score) for endurance performance. There was no association between the TGS and endurance athlete status (Control: 49.0 ± 7.6, Regional: 47.3 ± 7.6, National: 49.1 ± 5.7, and International: 48.2 ± 7.0, P = 0.626). These results suggested that TGS s based on the 21 previously published endurance performance‐associated polymorphisms do not influence endurance running performance in the Japanese population. Nevertheless, some marginal tendencies have to be noted: the frequencies of the ACTN 3 R577X rs1815739 RR + RX genotype and the GNB 3 rs5443 CC + CT genotype were higher in international athletes than in controls (85% vs. 73.6%, P = 0.042 and 90% vs. 76%, P = 0.007, respectively), but not significantly different after Bonferroni correction.