Open AccessAlteration of cardiac autonomic function in patients with newly diagnosed epilepsy
Author(s) -
Goit Rajesh K.,
Jha Santosh K.,
Pant Bhawa.
Publication year - 2016
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12826
Subject(s) - poincaré plot , heart rate variability , supine position , epilepsy , medicine , cardiology , autonomic function , heart rate , anesthesia , blood pressure , psychiatry
The aim of the study was to determine if heart rate variability ( HRV ) showed any changes in patients with newly diagnosed epilepsy in comparison with controls. Sixty‐five patients with epilepsy (38 males and 27 females), aged 30–50 years, who had never previously received treatment with antiepileptic drugs were eligible for inclusion in this study. Resting electrocardiogram ( ECG ) at spontaneous respiration was recorded for 5 min in supine position. Time‐domain analysis, frequency‐domain analysis, and Poincare plot of HRV were recorded from ECG . In time‐domain measures, the square root of the mean of the sum of the squares of differences between adjacent RR intervals ( RMSSD ) and percentage of consecutive RR intervals that differ by more than 50 msec ( pNN 50) were significantly less in patients with epilepsy. In frequency‐domain measures, high frequency [( HF ) msec 2 ], HF (nu), and low frequency [ LF (msec 2 )] were significantly less in patients with epilepsy while LF (nu) and LF / HF were significantly high in patients with epilepsy. In Poincare plot, standard deviation perpendicular to line of Poincare plot ( SD 1) and standard deviation along the line of entity in Poincare plot ( SD 2) were significantly less in patients with epilepsy. Our results suggest that epileptic patients have an impact on the cardiac autonomic function as measured by HRV .