Open AccessSignificant obesity‐associated gene expression changes occur in the stomach but not intestines in obese mice
Author(s) -
Chen Jing,
Chen Lihong,
Sanseau Philippe,
Freudenberg Johannes M.,
Rajpal Deepak K.
Publication year - 2016
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12793
Subject(s) - stomach , obesity , endocrinology , medicine , gastrointestinal tract , gene expression , gene , transcriptome , diabetes mellitus , gastrin , biology , secretion , genetics
The gastrointestinal ( GI ) tract can have significant impact on the regulation of the whole‐body metabolism and may contribute to the development of obesity and diabetes. To systemically elucidate the role of the GI tract in obesity, we performed a transcriptomic analysis in different parts of the GI tract of two obese mouse models: ob/ob and high‐fat diet ( HFD ) fed mice. Compared to their lean controls, significant changes in the gene expression were observed in both obese mouse groups in the stomach (ob/ob: 959; HFD : 542). In addition, these changes were quantitatively much higher than in the intestine. Despite the difference in genetic background, the two mouse models shared 296 similar gene expression changes in the stomach. Among those genes, some had known associations to obesity, diabetes, and insulin resistance. In addition, the gene expression profiles strongly suggested an increased gastric acid secretion in both obese mouse models, probably through an activation of the gastrin pathway. In conclusion, our data reveal a previously unknown dominant connection between the stomach and obesity in murine models extensively used in research.