Open AccessRoutine daily physical activity and glucose variations are strongly coupled in adults with T1 DM
Author(s) -
Farabi Sarah S.,
Carley David W.,
Cinar Ali,
Quinn Lauretta
Publication year - 2015
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12644
Subject(s) - physical activity , medicine , bioinformatics , biology , physical medicine and rehabilitation
Type 1 Diabetes (T1 DM ) is characterized by altered glucose homeostasis resulting in wide glucose variations throughout a 24‐h period. The relationship between routine daily physical activity and glucose variations has not been systematically investigated in adults with T1 DM . The objectives of this study were to characterize and quantify the relationship between routine daily activity and glucose variations in a small group of adults with T1 DM . Adults with T1 DM treated with an insulin pump were recruited for the study. Over a 3‐day period, glucose variations were monitored with a continuous glucose monitoring system ( CGMS ) and routine daily physical activity was assessed using an accelerometer‐based physical activity‐monitoring band. Simultaneous glucose and physical activity data for one 24‐h period were used for analysis. Cross‐correlation function and wavelet coherence analyses were employed to quantify the coupling between physical activity and glucose. Twelve subjects were included in the analysis. Cross‐correlation function analysis revealed strong coupling between activity and glucose. Wavelet Coherence demonstrated that slower oscillations (120–340 min) of glucose and physical activity exhibited significantly greater coherence ( F = 12.6, P < 0.0001) than faster oscillations (10 and 120 min). Physical activity and glucose demonstrate strong time and frequency‐dependent coupling throughout a 24‐h time period in adults with T1 DM .