Open AccessWhat is the effect of ischemic preconditioning on the kinetics of pulmonary oxygen uptake and muscle deoxygenation during exercise?
Author(s) -
SabinoCarvalho Jeann L. C.,
Barbosa Thales Coelho,
Silva Bruno Moreira
Publication year - 2015
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12540
Subject(s) - deoxygenation , ischemic preconditioning , context (archaeology) , medicine , cardiology , time trial , exercise intensity , skeletal muscle , ischemia , chemistry , heart rate , biochemistry , blood pressure , biology , paleontology , catalysis
Ischemic preconditioning (IPC, brief cycles of ischemia) induces protection against ischemia–reperfusion injury, due to IPC‐mediated change in the metabolism of skeletal muscles and micro‐ and macrovascular function. Since high‐intensity aerobic exercise depends on such physiological factors, it has been hypothesized that IPC can also improve exercise performance. Although some studies confirmed this hypothesis (Salvador et al. 2015), others did not (Salvador et al. 2015). Moreover, even when IPC improved exercise performance, the mechanisms involved were unclear. For example, increase in maximal oxygen consumption (VO2max) (De Groot et al. 2010) and decrease in blood lactate concentration (Bailey et al. 2012) have been reported, but these findings were not unanimous among studies (Salvador et al. 2015).In this context, a recent study by Kido et al. (2015) examined the effects of IPC of the lower limbs on the kinetics of pulmonary VO2 and muscle deoxygenation during square‐wave transitions from low‐ to moderate‐intensity and from moderate‐ to severe‐intensity cycling exercise. Besides, authors assessed the effect of IPC on the time to exhaustion in the severe‐intensity workload. Authors found that IPC increased the time to exhaustion, which supports an increase in exercise performance. Furthermore, IPC did not change the pulmonary VO2 kinetics, but changed the kinetics of muscle deoxygenation. These findings are original and advance the …