Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E | Zendy

Díaz Víctor | Zendy; Peinado Ana B. | Zendy; BarbaMoreno Laura | Zendy; Altamura Sandro | Zendy; Butragueño Javier | Zendy; GonzálezGross Marcela | Zendy; Alteheld Birgit | Zendy; Stehle Peter | Zendy; Zapico Augusto G. | Zendy; Muckenthaler Martina U. | Zendy; Gassmann Max | Zendy

Open Access

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E

Author(s) -

Díaz Víctor,

Peinado Ana B.,

BarbaMoreno Laura,

Altamura Sandro,

Butragueño Javier,

GonzálezGross Marcela,

Alteheld Birgit,

Stehle Peter,

Zapico Augusto G.,

Muckenthaler Martina U.,

Gassmann Max

Publication year - 2015

Publication title -

physiological reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 39

ISSN - 2051-817X

DOI - 10.14814/phy2.12475

Subject(s) - hepcidin , athletes , medicine , iron deficiency , iron status , endocrinology , iron supplementation , serum iron , downregulation and upregulation , regulator , inflammatory response , inflammation , physiology , physical therapy , anemia , biology , biochemistry , gene

Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin‐6 ( IL ‐6) elevation. In this study performed on noniron deficient and well‐trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28‐days supplementation period with vitamins C (500 mg/day) and E (400 IU /day).

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