Open AccessElevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
Author(s) -
Díaz Víctor,
Peinado Ana B.,
BarbaMoreno Laura,
Altamura Sandro,
Butragueño Javier,
GonzálezGross Marcela,
Alteheld Birgit,
Stehle Peter,
Zapico Augusto G.,
Muckenthaler Martina U.,
Gassmann Max
Publication year - 2015
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12475
Subject(s) - hepcidin , athletes , medicine , iron deficiency , iron status , iron supplementation , endocrinology , serum iron , regulator , inflammatory response , downregulation and upregulation , inflammation , vitamin c , vitamin , iron homeostasis , physical therapy , metabolism , anemia , chemistry , biochemistry , gene
Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin‐6 ( IL ‐6) elevation. In this study performed on noniron deficient and well‐trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28‐days supplementation period with vitamins C (500 mg/day) and E (400 IU /day).