Open AccessTime‐ and dose‐dependent effects of total‐body ionizing radiation on muscle stem cells
Author(s) -
Masuda Shinya,
Hisamatsu Tsubasa,
Seko Daiki,
Urata Yoshishige,
Goto Shinji,
Li TaoSheng,
Ono Yusuke
Publication year - 2015
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12377
Subject(s) - hormesis , ionizing radiation , stem cell , population , medicine , dose–response relationship , irradiation , cell , cancer research , biology , physiology , toxicology , microbiology and biotechnology , oxidative stress , biochemistry , physics , environmental health , nuclear physics
Exposure to high levels of genotoxic stress, such as high‐dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low‐dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of total‐body γ ‐ray radiation on muscle stem cells, called satellite cells. Adult C57 BL /6 mice were exposed to γ ‐radiation at low‐ to high‐dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self‐renewal of satellite cells were observed in low‐dose radiation‐exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell‐derived progeny was slightly decreased in mice exposed to low‐dose radiation. Taken together, low‐dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice.