Open AccessAssociation between muscle hydration measures acquired using bioelectrical impedance spectroscopy and magnetic resonance imaging in healthy and hemodialysis population
Author(s) -
Sawant Anuradha,
House Andrew A.,
Chesworth Bert M.,
Connelly Denise M.,
Lindsay Robert,
Gati Joe,
Bartha Robert,
Overend Tom J.
Publication year - 2015
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12219
Subject(s) - bioelectrical impedance analysis , magnetic resonance imaging , medicine , skeletal muscle , hemodialysis , population , gastrocnemius muscle , extracellular fluid , chemistry , extracellular , body mass index , radiology , environmental health , biochemistry
Establishing the effect of fluctuating extracellular fluid ( ECF ) volume on muscle strength in people with end‐stage renal disease ( ESRD ) on hemodialysis ( HD ) is essential, as inadequate hydration of the skeletal muscles impacts its strength and endurance. Bioelectrical impedance spectroscopy ( BIS ) has been a widely used method for estimating ECF volume of a limb or calf segment. Magnetic resonance imaging ( MRI )‐acquired transverse relaxation times ( T 2 ) has also been used for estimating ECF volumes of individual skeletal muscles. The purpose of this study was to determine the association between T 2 (gold standard) of tibialis anterior ( TA ), medial ( MG ), and lateral gastrocnemius ( LG ), and soleus muscles and calf BIS ECF , in healthy and in people with ESRD / HD . Calf BIS and MRI measures were collected on two occasions before and after HD session in people with ESRD / HD and on a single occasion for the healthy participants. Linear regression analysis was used to establish the association between these measures. Thirty‐two healthy and 22 participants on HD were recruited. The association between T 2 of TA , LG , MG , and soleus muscles and ratio of calf BIS ‐acquired ECF and intracellular fluids ( ICF ) were: TA : β = 0.30, P > 0.05; LG : β = 0.37, P = 0.035; MG : β = 0.43, P = 0.014; soleus: β = 0.60, P < 0.001. For the HD group, calf ECF was significantly associated with T 2 of TA ( β = 0.44, P = 0.042), and medial gastrocnemius ( β = 0.47, P = 0.027) following HD only. Hence BIS ‐acquired measures cannot be used to measure ECF volumes of a single muscle in the ESRD / HD population; however, BIS could be utilized to estimate ratio of ECF : ICF in healthy population for the LG , MG , and soleus muscles.