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Reduced inhibitory gate in the barrel cortex of N euroligin3 R451C knock‐in mice, an animal model of autism spectrum disorders
Author(s) -
Cellot Giada,
Cherubini Enrico
Publication year - 2014
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12077
Subject(s) - inhibitory postsynaptic potential , animal model , barrel (horology) , neuroscience , autism , physics , biology , medicine , psychiatry , engineering , mechanical engineering
Neuroligins are postsynaptic adhesion molecules that interacting with presynaptic neurexins ensure the cross‐talk between pre‐ and postsynaptic specializations. Rare mutations in neurexin–neuroligin genes have been linked to autism spectrum disorders ( ASD s). One of these, the R 451 C mutation of the gene encoding for N euroligin3 ( Nlgn3 ), has been found in patients with familial forms of ASD s. Animals carrying this mutation ( NL 3 R451C knock‐in mice) exhibit impaired social behaviors, reminiscent of those observed in ASD patients, associated with major alterations in both GABA ergic and glutamatergic transmission, which vary among different brain regions and at different developmental stages. Here, pair recordings from parvalbumin‐ ( PV ) expressing basket cells and spiny neurons were used to study GABA ergic synaptic signaling in layer IV barrel cortex of NL 3 R451C mutant mice. We found that the R 451 C mutation severely affects the probability of GABA release from PV ‐expressing basket cells, responsible for controlling via thalamo‐cortical inputs the feed‐forward inhibition. No changes in excitatory inputs to parvalbumin‐positive basket cells or spiny neurons were detected. These data clearly show that primary targets of the NL 3 mutation are PV ‐expressing basket cells, independently of the brain region where they are localized. Changes in the inhibitory gate of layer IV somatosensory cortex may alter sensory processing in ASD patients leading to misleading sensory representations with difficulties to combine pieces of information into a unified perceptual whole.

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