Open AccessLeukocyte margination at arteriole shear rate
Author(s) -
Takeishi Naoki,
Imai Yohsuke,
Nakaaki Keita,
Yamaguchi Takami,
Ishikawa Takuji
Publication year - 2014
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12037
Subject(s) - arteriole , shear (geology) , microvillus , biophysics , chemistry , channel (broadcasting) , mechanics , shear rate , materials science , biology , medicine , physics , microcirculation , composite material , membrane , biochemistry , engineering , electrical engineering , viscosity
We numerically investigated margination of leukocytes at arteriole shear rate in straight circular channels with diameters ranging from 10 to 22 μ m. Our results demonstrated that passing motion of RBC s effectively induces leukocyte margination not only in small channels but also in large channels. A longer time is needed for margination to occur in a larger channel, but once a leukocyte has marginated, passing motion of RBC s occurs continuously independent of the channel diameter, and leukocyte margination is sustained for a long duration. We also show that leukocytes rarely approach the wall surface to within a microvillus length at arteriole shear rate.