Open AccessSex differences in blood pressure control in SHR : lack of a role for EET s
Author(s) -
Moulana Mohadetheh,
Hosick Karen,
Stanford James,
Zhang Huimin,
Roman Richard J.,
Reckelhoff Jane F.
Publication year - 2014
Publication title -
physiological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 39
ISSN - 2051-817X
DOI - 10.14814/phy2.12022
Subject(s) - epoxide hydrolase 2 , blood pressure , mean arterial pressure , medicine , endocrinology , epoxyeicosatrienoic acid , biology , enzyme , metabolism , cytochrome p450 , biochemistry , heart rate
The mechanisms responsible for the gender difference in blood pressure ( BP ) in humans are not clear. Over the past several years we have studied the spontaneously hypertensive rat ( SHR ) as a model of sex differences in BP control. In the present study, we tested the hypothesis that renal vascular and microsomal epoxyeicosatrienoic acid ( EET ) levels are higher in females than males, and increasing vascular EET s by blocking epoxide hydrolase with AUDA will reduce BP more in males than females. Renal vascular and microsomal EET s were higher in female SHR than males. Mean arterial pressure ( MAP by telemetry) was higher in males than females during the baseline period of 6 days, and although the epoxide hydrolase inhibitor, AUDA , given for 10 days increased renal microvascular EET s in both groups, AUDA did not affect MAP in either group. These data suggest that EET s do not contribute to the sex differences in hypertension in young SHR .