Open AccessMammary epithelial polarity and macrophage infiltration
Author(s) -
Ren Xu
Publication year - 2018
Publication title -
macrophage
Language(s) - English
Resource type - Journals
ISSN - 2378-136X
DOI - 10.14800/macrophage.1521
Subject(s) - inflammation , polarity (international relations) , infiltration (hvac) , cell polarity , microbiology and biotechnology , epithelium , epithelial polarity , macrophage , biology , chemistry , cell , pathology , immunology , medicine , materials science , in vitro , biochemistry , composite material
Loss of epithelial cell polarity and inflammation are hallmarks of breast cancer development. Although the association between the disruption of tissue polarity and inflammation has been demonstrated, we know little about how these two events are coupled. Using the 3D co-culture model of mammary epithelial cells and monocytes, a recent study reveals a link between disruption of epithelial polarity and monocytes infiltration.