Open AccessAmeliorating Effects of Adalimumab on Rabbits with Experimental Cerebral Vasospasm After Subarachnoid Hemorrhage
Author(s) -
Gökhan Toğuşlu,
Mehmet Fatih Erdi,
Densel Araç,
Fatıh Keskin,
İbrahim Kılınç,
Gökhan Cüce
Publication year - 2020
Publication title -
ulusal travma ve acil cerrahi dergisi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.28
H-Index - 22
ISSN - 1306-696X
DOI - 10.14744/tjtes.2019.52504
Subject(s) - subarachnoid hemorrhage , medicine , cerebral vasospasm , vasospasm , anesthesia
Adalimumab (ADA), which is a new-generation recombinant human monoclonal antibody for tumor necrosis factor α (TNFα), has strong anti-inflammatory effects. The role of enhanced inflammation is well established for the development and progression of cerebral vasospasm. Investigated in the present study is the probable ameliorating and neuroprotective effects of ADA in rabbits using a cerebral vasospasm model with biochemical and histopathological methods.