Open AccessA Novel Hemostatic Scaffold Material and The Importance of Scaffold Formation on Ending Hemorrhage: An Experimental Rat Study
Author(s) -
İsmail Altıntop,
Mehmet Tatlı,
Zeynep Soyer,
Arzu Hanım Yay,
Ahmet Öztürk,
Çiğdem Karakükçü
Publication year - 2019
Publication title -
ulusal travma ve acil cerrahi dergisi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.28
H-Index - 22
ISSN - 1306-696X
DOI - 10.14744/tjtes.2019.34359
Subject(s) - scaffold , hemostasis , chitosan , hemostatic agent , fibrin , scanning electron microscope , medicine , rat model , coagulation , biomedical engineering , surgery , chemistry , materials science , immunology , biochemistry , composite material
Different pharmacological agents are developed to control bleeding. However, it is critical for these agents to induce thrombin formation and have an effect on vasoconstriction, coagulation, and scaffold. In this study, we aimed to demonstrate the agents' ability to stop bleeding properties on minor and major open bleedings after skin clefts, extracorporal injuries, traumatic cuts, spontaneous or surgical intervention besides scaffold properties. For this purpose, a new and authentic hemostatic agent, processed diatomite (PD) and the most preferred chitosan in the medical area were used to test blood stopping and scaffold effects in a rat femoral bleeding model. The samples were examined by scanning electron microscopy (SEM), and the results on blood stopping were shared.