Open AccessRelationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population
Author(s) -
Şule Darbaş
Publication year - 2021
Publication title -
i̇stanbul kuzey klinikleri
Language(s) - English
Resource type - Journals
ISSN - 2148-4902
DOI - 10.14744/nci.2021.00018
Subject(s) - abacavir , allele , human leukocyte antigen , immunology , allele frequency , hla b , biology , typing , hla b antigens , population , hla a , medicine , viral load , antigen , human immunodeficiency virus (hiv) , genetics , gene , antiretroviral therapy , environmental health
Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye.