Open AccessThe Relationship between Coronary Artery Disease and SIRT1 Protein
Author(s) -
Lütfü Aşkın,
Hakan Tıbıllı,
Okan Tanrıverdi,
Serdar Türkmen
Publication year - 2020
Publication title -
i̇stanbul kuzey klinikleri
Language(s) - English
Resource type - Journals
ISSN - 2148-4902
DOI - 10.14744/nci.2020.31391
Subject(s) - sirtuin 1 , sirtuin , endothelial dysfunction , inflammation , coronary artery disease , monocyte , angiogenesis , ischemia , medicine , endothelial stem cell , disease , reperfusion injury , immunology , cancer research , biology , downregulation and upregulation , biochemistry , in vitro , gene , acetylation
Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preventing endothelial dysfunction and reperfusion injury due to ischemia. Suppression of SIRT1 causes monocyte affinity due to endothelial dysfunction. Sirtuins activators are involved in pathologies of many diseases with promising treatments. The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.