Open AccessRelationship Between Serum Matrix Metalloproteinase and Myocardial Fibrosis Detected with Cardiac MRI in Heart Failure Patients with Reduced Ejection Fraction
Author(s) -
Ömer Çelik
Publication year - 2020
Publication title -
the anatolian journal of cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.364
H-Index - 28
eISSN - 2149-2271
pISSN - 2149-2263
DOI - 10.14744/anatoljcardiol.2020.54937
Subject(s) - ejection fraction , medicine , cardiology , myocardial fibrosis , heart failure , matrix metalloproteinase , fibrosis
A strong correlation exists between myocardial fibrosis and heart failure (HF). Myocardial fibrosis can be detected by cardiac magnetic resonance (CMR), which is a crucial noninvasive imaging method with high specificity and sensitivity. Matrix metalloproteinases (MMPs) are primary proteases responsible for the degradation of extracellular matrix (ECM) components, and they play a vital role in maintaining the balance between anabolism and catabolism of ECM. This study aims to investigate the correlation between cardiac fibrosis detected on CMR and serum MMP-9 levels in patients with HF.