Open AccessProtective effects of trimetazidine and coenzyme Q10 on cisplatin-induced cardiotoxicity by alleviating oxidative stress and mitochondrial dysfunction
Author(s) -
Li Zhao
Publication year - 2019
Publication title -
the anatolian journal of cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.364
H-Index - 28
eISSN - 2149-2271
pISSN - 2149-2263
DOI - 10.14744/anatoljcardiol.2019.83710
Subject(s) - coenzyme q10 , oxidative stress , malondialdehyde , superoxide dismutase , pharmacology , trimetazidine , catalase , viability assay , cisplatin , cardiotoxicity , reactive oxygen species , medicine , apoptosis , antioxidant , cytochrome c , chemistry , biochemistry , chemotherapy
The objective of this study was to investigate the effects of trimetazidine (TMZ) and coenzyme Q10 (CoQ10) on cisplatin-induced cardiotoxicity in rat cardiomyocytes.