Open AccessAcute Lymphoblastic Leukemia Following Incomplete Kawasaki Disease
Author(s) -
Miguel García-Domínguez,
Julio Cesar Valadez,
Edgardo Tostado-Morales,
Jorge Luis Guzman-Rendon,
Giordano PérezGaxiola,
Edna Venegas-Montoya
Publication year - 2020
Publication title -
journal of medical cases
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1923-4163
pISSN - 1923-4155
DOI - 10.14740/jmc3569
Subject(s) - medicine , kawasaki disease , neutropenia , macrophage activation syndrome , etiology , vasculitis , lymphoblastic leukemia , leukemia , immunology , disease , artery , toxicity
Kawasaki disease (KD) is a multisystemic vasculitis of unknown etiology, typically affecting children younger than 5 years of age. A direct relationship between KD and the development of malignant tumors has not been demonstrated, however, the immunological alterations of KD could be associated with its development. An 11-month-old male was diagnosed with incomplete KD. No coronary abnormalities were detected. He was treated with intravenous immunoglobulin (IVIG) and aspirin. Four weeks later, he developed fever, otitis media, bullous pharyngitis, irritability, anemia and hyperleukocytosis, and neutropenia. Blasts forms were observed in peripheral blood. Bone marrow smear demonstrated acute lymphoblastic leukemia (ALL). KD has diverse clinical presentations, atypical manifestations, and several complications such as macrophage activation syndrome. As our case highlights, lymphoid neoplasms may follow KD.