Open AccessA Patient With Human Herpesvirus 8-Positive Multicentric Castleman’s Disease Who Met Criteria for TAFRO Syndrome: Controversy in Practice?
Author(s) -
María Cynthia Fuentes-Lacouture,
Carmen Cecilia Gómez,
Martha Romero,
Andrés Borda,
Iván Noreña,
Julián Alberto Naranjo
Publication year - 2020
Publication title -
journal of medical cases
Language(s) - English
Resource type - Journals
eISSN - 1923-4163
pISSN - 1923-4155
DOI - 10.14740/jmc3523
Subject(s) - medicine , organomegaly , anasarca , castleman disease , cytopenia , disease , human herpesvirus , pathology , human immunodeficiency virus (hiv) , immunology , bone marrow
Multicentric Castleman's disease (MCD) is a known entity with characteristics of lymphoproliferative syndrome, characterized by cytokine activation. Its association with human immunodeficiency virus (HIV) is frequently described, as well as its positivity for human herpesvirus 8 (HHV-8). However, some negative patients for the latter (called idiopathic MCD), may have an aggressive spectrum of the disease (characterized by the presence of cytopenia, renal failure, anasarca and organomegaly), known as TAFRO syndrome (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly). We present the case of a young patient recently diagnosed with HIV infection, in whom MCD was found, and with an aggressive course despite treatment, who met criteria for TAFRO syndrome despite HHV-8 positivity.