Open AccessHuman Papillomavirus – Role in Cervical Carcinogenesis and Methods of Detection
Author(s) -
Martin Bartošík,
Roman Hrstka,
Ludmila Jiráková
Publication year - 2018
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.14735/amko201889
Subject(s) - carcinogenesis , cervical intraepithelial neoplasia , dna methylation , cancer research , microrna , cervical screening , medicine , cervical cancer , biology , oncology , gene , gene expression , cancer , genetics
Persistent infection with high-risk human papillomavirus (HPV) strains, especially HPV 16 and HPV 18, is associated with the onset of various malignant diseases, including cervical carcinoma in women. HPV DNA testing is thus being implemented as a complementary method to standard cytological examination, mainly due to its increased sensitivity.