Open AccessDown-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes by Lactobacillus rhamnosus GG and Lactobacillus crispatus SJ-3C-US supernatants in HeLa cell line
Author(s) -
Zahra Nouri,
Nadia Neyazi,
Mohammad Hossein Modarressi,
Fatemeh Karami,
Atieh Abedin-Do,
Zahra TaherianEsfahani,
Soudeh GhafouriFard,
Elahe Motevaseli
Publication year - 2018
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.14735/amko2018429
Subject(s) - hela , lactobacillus rhamnosus , biology , lactobacillus crispatus , cancer , cell culture , cancer research , lactobacillus , cancer cell , epigenetics , microbiology and biotechnology , gene , genetics , bacteria
Cancer testis antigens (CTAs) are considered cancer bio-markers due to their highly specific expression pattern in human malignancies and near absence from normal somatic tissues. Their specific expression has made them potential targets for early dia-gnosis, assessment of patients prognosis and treatment of cancer in recent years. Lactobacilli are a group of probio-tics with anti-cancer, immunomodulatory and other beneficial features. These bacteria have been shown to alter expression of several cancer-related genes.