Open AccessMeta-Analysis of BRCA1 Polymorphisms and Breast Cancer Susceptibility
Author(s) -
Soudeh GhafouriFard,
Ali Dianatpour,
Sepideh Faramarzi
Publication year - 2018
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.14735/amko2018330
Subject(s) - single nucleotide polymorphism , meta analysis , breast cancer , genetics , allele , odds ratio , biology , genotype , gene , oncology , cancer , medicine
BRCA1 codes for a tumor suppressor protein involved in DNA repair. Based on the role of single nucleotide polymorphisms (SNPs) in the modification of gene expression and function and the existence of certain SNPs within 3-untranslated region of BRCA1 with the ability to change binding sites for mirRNAs, several association studies have been designed to explore the significance of SNPs within BRCA1 gene in conferring breast cancer (BC) risk. This study aims to assess the relationship between BRCA1 SNPs and BC using meta-analysis.