Open AccessExpression and Functional Characterization of miR-34c in Cervical Cancer
Author(s) -
Lucia Sommerová,
Hedvika Fraňková,
Milan Anton,
Eva Jandáková,
Bořivoj Vojtěšek,
Roman Hrstka
Publication year - 2018
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.14735/amko20182s82
Subject(s) - cervical cancer , microrna , blot , biology , downregulation and upregulation , cancer research , transfection , cell growth , cancer , cell , gene expression , cell culture , pathology , gene , medicine , genetics
Cervical cancer is the fourth most common cancer in women and is usually associated with human papillomavirus infection. Viral infections are usually characterized by morphological changes of epithelial cells; however, it is difficult to determine using recently available screening methods whether the changes are caused by productive infection or by malignant disease. Thus, new efforts are required to find novel diagnostic biomarkers of cervical cancer, such as miRNAs, which are small non-coding RNAs involved in the regulation of gene expression.