Open AccessMiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells
Author(s) -
Wang Zhi,
Feng Qu,
Mingzhu Zhang
Publication year - 2022
Publication title -
cellular and molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.371
H-Index - 71
eISSN - 1165-158X
pISSN - 0145-5680
DOI - 10.14715/cmb/2022.68.1.18
Subject(s) - osteosarcoma , microrna , wnt signaling pathway , cell growth , cancer research , drug , doxorubicin , drug resistance , biology , cell , mechanism (biology) , microbiology and biotechnology , chemistry , signal transduction , pharmacology , chemotherapy , gene , genetics , philosophy , epistemology
MicroRNAs (miRNAs) have been documented to function differently in numerous human cancers. Our study planned to investigate the role of microRNA-140 (miR-140) and to identify its possible target in osteosarcoma (OS) to predict their mechanism in OS. The miR-140 was down-regulated in OS, and its high expression decreased MG63 cell proliferation. At the molecular level, Wnt1 was a target of miR-140, and its expression could be suppressed by miR-140. Besides, miR-140 overexpression decreased drug resistance in OS cells treated by doxorubicin. Collectively, overexpression of miR-140 may inhibit human OS cell proliferation and may enhance drug sensitivity by direct regulation of Wnt/β-catenin signaling.