Open AccessPiceatannol mediated regulation of deregulated signaling pathways in different cancers: Tumbling of the ninepins of molecular oncology
Author(s) -
Sawera Nayyab,
Humaira Naureen,
Areesha Maryam,
Rükset Attar,
Uteuliyev Yerzhan Sabitaliyevich,
Konysbayeva Kenzhekul Konysbayevna,
Ammad Ahmad Farooqi
Publication year - 2020
Publication title -
cellular and molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.371
H-Index - 71
eISSN - 1165-158X
pISSN - 0145-5680
DOI - 10.14715/cmb/2020.66.6.27
Subject(s) - piceatannol , wnt signaling pathway , microrna , signal transduction , cancer research , computational biology , biology , pi3k/akt/mtor pathway , drug discovery , medicine , bioinformatics , pharmacology , microbiology and biotechnology , genetics , gene , resveratrol
With the recent technological advancements, a new golden era of natural products drug discovery has dawned. Increasingly it is being realized that structural modularity of many pharmacologically active products derived natural sources allows a building-block approach which can be exploited for analysis of regulation of deregulated oncogenic protein networks in different cancers. Piceatannol has been shown to effectively modulate JAK/STAT, Wnt/β-catenin, mTOR pathway in different cancers. In addition, certain hints have emerged which shed light on the regulation of microRNAs by piceatannol in some cancers. Regulation of deregulated oncogenic pathways by Piceatannol is gradually capturing attention and might be helpful in the multi-targeting of deregulated oncogenic networks in cancers.