Open AccessDelayed Puberty in Girls with Primary Amenorrhea: A Report of Cases
Author(s) -
Fatinah Shahab,
Inu Mulyantoro,
Hary Tjahjanto,
Tri Indah Winarni,
Sultana Mh Faradz
Publication year - 2021
Publication title -
journal of biomedicine and translational research
Language(s) - English
Resource type - Journals
ISSN - 2503-2178
DOI - 10.14710/jbtr.v7i2.12054
Subject(s) - amenorrhea , luteinizing hormone , primary amenorrhea , breast development , turner syndrome , gonadal dysgenesis , secondary sex characteristic , hypoplasia , estrogen , medicine , gynecology , follicle stimulating hormone , endocrinology , physiology , hormone , biology , pregnancy , genetics
Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen. Delayed puberty with primary amenorrhea in female is the lack of breast development followed by the absence of menses 3 years after the initiation of breast development. Sex chromosomes have an important role in determining the sex, germ cell differentiation of foetus, and reproductive functions of an offspring, thus, sex chromosomal aberrations frequently cause primary amenorrheaCase presentation: We report two delayed puberty cases with the chief complain of primary amenorrhea. Both cases showed hypoplasia of uterus and ovaries on pelvic imaging and hormonal assay showed low of FSH. The first case was gonadal dysgenesis with 46,XX karyotype and low level of estrogen and the second case was a turner syndrome with 45,X karyotype and normal level of estrogen. Conclusion:This study reported delayed puberty with primary amenorrhea cases due to different chromosomal aberration pattern which have similar clinical features. Therefore, cytogenetic examination is needed for any primary amenorrhea cases in order to accomplish the confirmatory diagnosis and for the clinicians to make a correct intervention and treatment.