Open AccessAntimicrobial, Antioxidant, Hemolytic Activities and Toxicity of Ethyl Acetate Extract From an Unidentified Coral-Associated Fungus, Aspergillus brevipes RK06
Author(s) -
Risa Nofiani,
Rio Kurniadi,
Puji Ardiningsih
Publication year - 2011
Publication title -
iscc (indonesian journal of cancer chemoprevention)
Language(s) - English
Resource type - Journals
eISSN - 2355-8989
pISSN - 2088-0197
DOI - 10.14499/indonesianjcanchemoprev2iss2pp212-216
Subject(s) - antimicrobial , hemolysis , antioxidant , microbiology and biotechnology , ethyl acetate , biology , aspergillus ochraceus , artemia salina , lipid peroxidation , aspergillus fumigatus , staphylococcus aureus , traditional medicine , biochemistry , chemistry , toxicity , food science , bacteria , mycotoxin , medicine , genetics , organic chemistry , ochratoxin a , immunology
Marine fungi are one of the potential and prolific sources to produce unique and novel structure of bioactive compounds. The aim of this research was to explore the biological activities potency from ethyl acetate extract of Aspergillus brevipes RK06. A. brevipes RK06 was successfully isolated from an unidentified coral from Randayan Island, Kalimantan Barat. The extract inhibited the oxidation of linoleic acid (Ferric thiocyanate assay) with a lipid peroxidation inhibition value of 28.44%. The IC50 value of the extract for brine shrimp lethality test was 34.19ug/mL. The hemolytic percentage of the extract for hemolysis on cow erythrocytes was 5.21%. The extract showed a growth inhibition against Klebsiella pneumonia, Pseudomonas aeruginosa, and Staphylococcus aureus. Based on the assays, the extract showed a potential citotoxity and both low antioxidant and hemolytic activities.Keywords: antioxidant, hemolytic activity, antimicrobial, toxicity, Aspergillus brevipes RK06