Open AccessDesign and simulation of microfluidic device for the detection of HIV
Author(s) -
José Arturo Lagos-Sandoval,
Jorge Eduardo Salazar-Zuñiga,
Edwing Oswaldo Berdugo-Romero
Publication year - 2018
Publication title -
visión electrónica/visión electrónica
Language(s) - English
Resource type - Journals
eISSN - 2248-4728
pISSN - 1909-9746
DOI - 10.14483/22484728.18376
Subject(s) - microfluidics , particle (ecology) , human immunodeficiency virus (hiv) , reagent , materials science , filter (signal processing) , flow (mathematics) , stage (stratigraphy) , sort , nanotechnology , biomedical engineering , computer science , chemistry , engineering , mechanics , virology , physics , paleontology , oceanography , information retrieval , computer vision , biology , geology
This article presents a diagnostic device model, which by using chemical reagents and microfluidics that makes a sort of particle separation and was developed to diagnose an acquired viral immunodeficiency. The device allows to isolate leukocytes and apply a reagent that measures the presence or absence of this virus. The design on the other hand uses tools such as SolidWorks and Autodesk Simulation, which, with the rupture of the membranes and the separation of their components, allows the chemical reaction in the particles and the detection of the virus.
Based on the choice of particle analysis and validating the performance of the fluid maintained in the filter stage, which is represented by 5 flow lines, it shows the movement of 5 particles with the same diameter. Additionally, three tests were performed that varied the diameter of the particles to 5 μm, 10 μm and a larger diameter particle (15 μm). The results show that, with a diameter of 5 μm, the particles move smoothly and the filter can reach the next stage. The particles of 10 μm in diameter presented a normal blood flow, however, an obstruction in the particles of 15 μm in diameter can be observed.