Open AccessAsociación entre la exposición al frío y el asma: revisión sistemática y meta-análisis, 1965-2015
Author(s) -
Germán Zuluaga,
Iván Sarmiento Combariza,
Juan Pimentel,
Neil Andersson
Publication year - 2021
Publication title -
salud/salud uninorte
Language(s) - English
Resource type - Journals
eISSN - 2011-7531
pISSN - 0120-5552
DOI - 10.14482/sun.36.1.616.238
Subject(s) - observational study , meta analysis , asthma , odds ratio , medicine , confidence interval , subgroup analysis , common cold , effect modification , random effects model , demography , immunology , sociology
Objectives: to conduct a systematic review and a meta-analysis of observational and expe- rimental studies that explore the relation between asthma and cold exposure. Materials and methods: systematic review of experimental and observational studies pu- blished up to August 2015 in Pubmed, Embase and Lilacs. Two researchers selected studies that measured the occurrence of asthma in individuals exposed to different environmen- tal temperatures. A meta-analysis used RevMan 5.3’s random effects model to calculate a summary weighted Odds Ratio with 95% confidence intervals, and a sensitivity analysis identified the influence of each study. Subsequent subgroup analyses identified summary measures by type of cold exposure and study design. Additional analysis measured hetero- geneity and risk of bias. Results: we found 86 studies measuring the relation between cold exposure and asthma. We included 11.6% (10/86) of the studies in the meta-analysis and found an association between cold exposure and asthma with all the studies (ORw 2.0 95%CI 1.28-3.14), with the subgroup of experimental studies (ORw 3.8 IC95% 1.70-8.86), and with cold environmental air (ORw 1.59 IC95% 1.10-2.30). The studies had high risk of bias and statistical heteroge- neity [I2 : 63.1% (27%-81.4%)]. Conclusions: the results support the hypothesis of an association between asthma and cold exposure. This study encourages to explore the concepts proposed by traditional medi- cine to establish its benefits on prevention and care of respiratory diseases, such as asthma.